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Telethon donations fund early flu protection for bubs

Babies’ Breath Research

Babies worldwide could have access to life-saving influenza vaccinations from just eight weeks of age thanks to researchers at Telethon Kids Institute and the generous support of the Telethon community.

The first step in the Institute’s bold influenza research program, the FluBub Study launched this week will pave the way for a greater ambition – to develop a single flu injection that would cover against all strains of the disease, for life.

Associate Professor Chris Blyth, Co-Director of the Wesfarmers Centre of Vaccines and Infectious Diseases, based at Telethon Kids Institute, says data from this first study will play an essential role in helping to understand how the immune system responds to its first exposure to flu proteins, either through a vaccine or the infection.

“Young babies are the greatest risk of flu and its complications because the first exposure to the virus is often the most severe, striking when the immune system is still developing strength,” say A/Prof Blyth.

“While we know a flu vaccine in pregnancy passes protection from the mother to her newborn, this starts to wain from as early as two months of age, leaving babies at risk of flu and its complications when they are most vulnerable.

“The FluBub Study will investigate giving flu vaccine at two months of age instead of the current six months as per National Immunisation Program, allowing us to establish how immunological protection is generated and the potential advantages of early-life vaccination.

“From there, we will apply cutting-edge systems vaccinology approaches that will provide us with the key to truly unlock the secrets of flu immunity and inform future vaccine development,” says A/Prof Blyth.

The study is being guided by world-renowned vaccinology expert Professor Tobias Kollmann, who led the charge for Telethon Kids Institute to become the southern hemisphere’s only hub for the Human Vaccines Project – decoding the human immune system to enable people to live healthier, longer lives.

This ground-breaking research was made possible thanks to attendees at the 2019 Telethon Lexus Ball, who donated to support the Institute’s influenza research program after being inspired by the heart-breaking story shared by the DeLuis family.

Their two-year-old daughter Lucy sadly lost her life 12 months ago – just five days after being diagnosed with influenza – and her family are now dedicated to supporting research that will develop more effective weapons against the disease.

Researchers are looking for 150 WA mums and their babies to take part in the FluBub Study, with mothers aged 25 to 35 years invited to participate.

Visit the FluBub Study page on the Wesfarmers Centre of Vaccines and Infectious Disease website for more information, or email flububstudy@telethonkids.org.au to register your interest.

Healthy Strides for Telethon

Thanks to funding from Telethon, Telethon Kids Researchers are capturing babies’ breath in a bid to prevent long-term lung health complications in babies born prematurely.

Chronic lung disease is the main complications for babies born preterm – leading to breathing problems, constant infections, problems with exercise and even premature aging.

Researchers have captured the breath of preterm babies as well as healthy babies aged 12-18 months old over a period of 3 years. They developed a non-evasive way to capture the baby’s exhaled breath condensate – even in very preterm babies where it was previously not thought possible to capture enough vapour from their little lungs for analysis.

After analysing the samples in the lab, they have been able to pin point symptoms like inflammation and oxidative stress – all indicators for lung disease in these preterm babies – as well determine the disease severity. This early diagnosis tool is paving way for better monitoring, earlier interventions and ultimately better outcomes for preterm babies.